Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity
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چکیده
منابع مشابه
Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity
The thrombospondins (TSPs) are a family of matricellular proteins that regulate cellular phenotype through interactions with a myriad of other proteins and proteoglycans. We have identified a novel interaction of the members of the TSP gene family with stromal interaction molecule 1 (STIM1). This association is robust since it is preserved in Triton X-100, can be detected with multiple anti-TSP...
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Background: TMEM16A and 16B work as Cl-channel, while 16F works as phospholipid-scramblase. Function of other TMEM16 members is unknown. Results: Using TMEM16F cells, TMEM16C, 16D, 16F, 16G and 16J were shown to be lipid scramblases. Conclusion: Some TMEM16 members are divided into two Cl-channels and five lipid-scramblases. Significance: Learning biochemical function of TMEM16 family members i...
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BACKGROUND TMEM16A and 16B work as Cl(-) channel, whereas 16F works as phospholipid scramblase. The function of other TMEM16 members is unknown. RESULTS Using TMEM16F(-/-) cells, TMEM16C, 16D, 16F, 16G, and 16J were shown to be lipid scramblases. CONCLUSION Some TMEM16 members are divided into two Cl(-) channels and five lipid scramblases. SIGNIFICANCE Learning the biochemical function of...
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ژورنال
عنوان ژورنال: Matrix Biology
سال: 2014
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2014.05.004